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Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0 54 nM in HeLa-SURP-luc and CHO-SV40-luc cells does not significantly inhibit SV40 promoter activity but is observed to slightly inhibit the interaction of Survivin with XIAP YM155 down-regulates survivin and XIAP modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells Phase 2
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1-Oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine is a zwitterionic phospholipid used as a lipid component in model membranes and for preparing liposomes and other lipid assemblies in biochemical and biophysical research.
High purity suitable for research applications (99.8%).
White to off-white solid appearance and consistent quality.
Molecular formula C42H82NO8P; molecular weight 760.08 g/mol.
Suitable for liposome synthesis and membrane model systems.
Powder storage: -20°C for up to 3 years; in solvent: -80°C for 6 months, -20°C for 1 month.
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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QX 314 chloride (CAS 5369-03-9) is a quaternary lidocaine derivative characterized by low membrane permeability It selectively inhibits voltage-gated sodium (Na sup /sup ) channels on nociceptive neurons when delivered intracellularly Entry into neurons occurs via activation and permeation through the TRPV1 or TRPA1 channel pores often facilitated by co-application with agonists such as capsaicin In nociceptive neurons QX 314 chloride blocks Na sup /sup currents and suppresses excitability whereas it also induces prolonged blockade of motor neuron function This compound is employed in studies of pain signaling selective sensory or motor nerve inhibition and mechanisms of ion channel-mediated drug entry
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